Pyrilutamide KX-826 0.5% topical solution by Folliva Labs — 30 ml bottle, pre-mixed in the EU
Folliva Labs

Pyrilutamide 0.5% (KX-826)

  • Every batch tested by an independent lab before it ships
  • A newer antiandrogen for people who react to RU-58841
NEXT BATCH

We bottle in small runs so nothing sits around getting old. This one is between batches — leave your email and you'll hear the day the next one is filled, before it goes back on the site.

One email, when there's something to say. Nothing else.

Batch and date on every bottle
Discreet, tracked shipping
Formulated & tested in the EU
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How it differs from RU-58841

Same job, different design. Pyrilutamide is a newer molecule intended to act at the scalp and then break down rather than build up. Some men tolerate one better than the other. Run one receptor blocker or the other — not both at once.

What to expect, honestly

The human evidence for pyrilutamide is real but limited, and the full picture is not settled — so treat your own six-month photographs as the verdict that matters. Some early shedding as follicles reset is common. Judge it at six months, on pictures.

Suitability & safety

For research use only. Not a medicine, and the safety data is thinner than for approved options. Patch-test first, use one blocker at a time, and speak to a professional if you are unsure.

Batch & storage

Every bottle is stamped with its batch number, blend date and expiry. Store it cool, dry and out of direct light — it degrades with heat and daylight.

HOW IT WORKS

Same target as RU-58841. A different key.

Pattern hair loss comes down to one hormone delivering the same instruction to your follicles, cycle after cycle. Pyrilutamide blocks that instruction at the receptor — one of three ways Folliva does the same job.

  1. 01

    DHT reaches the follicle

    Testosterone converts into DHT. In a susceptible scalp it binds androgen receptors inside the follicle and tells it to shrink. The receptor is the lock; DHT is the key.

  2. 02

    The follicle miniaturises

    Each cycle that signal lands, the growth phase shortens and hair returns finer and weaker. This runs quietly for years before a mirror admits it.

  3. 03

    Pyrilutamide occupies the receptor

    It is a nonsteroidal androgen-receptor antagonist. It sits in the receptor so DHT cannot deliver its instruction — on the scalp, where the damage happens.

  4. 04

    Designed to stay local, then clear

    It is built to act at the scalp and break down rather than accumulate in the body — an antiandrogen you apply, not one you swallow.

Why you’d choose it over RU-58841

Same target, different molecule. The main reason to run pyrilutamide is tolerance: some men find it sits better on their scalp than RU. It is not stronger — it is an alternative route to the same receptor.

One blocker at a time

RU-58841, pyrilutamide and CB-03-01 all do the same job. Running both does not double the effect; it just doubles what can irritate your scalp. Pick one, give it six months, judge it on photographs.

What the evidence actually is

Pyrilutamide has human trial data — which puts it ahead of many topicals — but that data is still limited and the picture is not settled. It is a research compound, not an approved medicine. What we can be held to is the bottle: blended at 0.5% by us in the EU, lab-tested every batch, dated so you know how old yours is.

THE ROUTINE

It takes sixty seconds a day.

It comes as a spray pump. One application a day, onto a dry scalp.

  1. 01

    Count the pumps

    Six to seven pumps of the spray is roughly 1 ml — the daily dose. It is a spray pump, so you count it. More is not better: a receptor can only be occupied once.

  2. 02

    Apply to a dry scalp

    Part the hair and spray onto the skin over the thinning area, not the hair. The scalp is where the receptors are.

  3. 03

    Let it dry

    Spread it gently and let it dry fully. Nothing to wash out.

  4. 04

    Same time, every day

    Consistency beats quantity. Photograph the same spot monthly in the same light.

Research use only. Batch number, blend date and expiry are printed on the bottle.

WHAT TO EXPECT

Nothing happens for a while. That’s normal.

A receptor blocker holds the line before it grows anything back. The early months are quiet by design.

  1. WEEKS 0–4

    Baseline, maybe a shed

    Take your first photographs. Some shedding as follicles reset is common and reads like failure. It usually isn’t.

  2. MONTHS 1–2

    Shedding settles

    Loss slows before anything grows. This is where most people quit too early.

  3. MONTHS 3–4

    First new growth

    Fine, pale hairs at the hairline and temples — easy to miss without your baseline photo.

  4. MONTHS 6+

    An honest verdict

    Six months is the earliest fair judgement, and with pyrilutamide’s limited evidence your own photographs matter more than anyone’s claims.

MECHANISM COMPARISON

The options, side by side.

The common ways men treat male-pattern hair loss, compared on mechanism, side effects, evidence and cost.

The options, side by side.
FeatureRU-58841Topical antiandrogenCB-03-01Clascoterone, topical antiandrogenPyrilutamideKX-826, topical antiandrogenMinoxidilTopical growth stimulantOral finasterideSystemic DHT blockerKetoconazole shampooTopical antifungalGHK-CuCopper peptide, scalp supportNatural topicalsCaffeine, rosemary, saw palmettoDoing nothingBaseline
Mechanism
What it acts onThe androgen receptorThe androgen receptorThe androgen receptorPotassium channels, blood flow5-alpha-reductase. Lowers DHTFungus. Mildly, the receptorThe scalp skin itself. Not the hormoneSeveral weak effects. None well mapped
Where it actsScalpScalp. Broken down there by design, but measurable amounts still reach the bloodScalp, by designScalp. Some absorptionWhole bodyScalpScalpScalp
Side effects
No systemic or sexual side effectsPartlyDesigned to break down before it reaches the blood. No human data proves that it does.PartlyBuilt to break down in the skin, but blood levels measured for their scalp solution are similar to the acne cream's, so a smaller treated area is not a safety argument. In the acne studies 3 of 42 had brief adrenal suppression that cleared after stopping.PartlyBuilt to act locally. In the trials, safety was no different from placebo. The data is still thin. YesNot a hormonal drug. Rare heart-rate effects at high doses.NoLower libido and erectile problems in a minority of men. Most recover after stopping. Some report that they did not. YesTopical, barely absorbed YesA topical peptide. It does nothing to hormones, for better or worse. YesNothing here reaches your bloodstream in any amount that matters Yes
No scalp irritationPartlyThe alcohol carrier can dry or sting. That is the vehicle, not the compound.PartlyIn the hair trials local reactions matched the placebo liquid, but the placebo was the same carrier without the drug. The carrier is glycol-heavy and can dry the skin.PartlyUsually mild, but it does not suit everyoneNoItching and flaking are common. Mostly the propylene glycol. YesIt never touches your scalpPartlyCan dry the scalp with regular use YesGenerally well tolerated on skin. Patch-test anyway. YesIn the rosemary trial, less itching than minoxidil. Yes
What it does
Blocks DHT YesAt the receptor. A non-steroidal molecule. YesAt the receptor. Same target, a steroidal molecule. YesAt the receptor. Same target, non-steroidal like RU-58841.NoIt grows hair by a different route entirely YesLowers DHT at the sourcePartlyA weak antiandrogen at bestNoNot an antiandrogen. It does nothing to DHT.PartlySaw palmetto is a weak 5-alpha-reductase inhibitorNo
An antiandrogen you apply, not swallow Yes Yes YesNoTopical, but not an antiandrogenNoAn antiandrogen, but a tabletPartlyTopical, weakly antiandrogenicNoTopical, but not an antiandrogen at allPartlyTopical. Weakly, and only through saw palmetto.
Stimulates new growth on its ownNoIt takes the brake off. It adds nothing.NoIt takes the brake off. It adds nothing of its own.NoSame route. It removes suppression. YesThis is the one thing it is forNoSame idea: it removes suppressionNoNoIt looks after the scalp. It does not push growth.PartlyA little, in small trials. Nothing like minoxidil.
Also works on the scalp itselfNoNoNoNoNo YesClears the flaking and inflammation. The only antifungal here. YesThis is the whole job of it: the condition of the skin your follicles grow fromPartlySome anti-inflammatory effect. It is not an antifungal.
Evidence and approval
An approved medicine for hair lossNoA research compound. No approved human use, anywhere.NoThe same molecule has been an approved 1% acne cream in the US since 2020, but nothing containing it is approved for hair loss anywhere. Another company is expected to file in 2027.NoA research compound. No approved use, anywhere. The manufacturer is heading for a filing in China. YesApproved for male-pattern hair loss YesApproved, on prescriptionPartlyApproved as an antifungal, not for hair lossNoA peptide sold in cosmetics. No medicine containing it is approved anywhere.NoCosmetics. Nobody has taken them through approval.
Human evidence behind itNoNo completed human trials. None. YesTwo Phase 3 studies, 1,465 men, twelve months. Run by the company taking it through approval, on their formulation, not ours.PartlyPhase 3 trial data at 0.5% and 1.0%, which puts it ahead of most topicals. The results are the manufacturer's and are not yet published. YesDecades of randomised trials YesDecades of randomised trials, and the longest evidence base of anything on this tablePartlyA handful of small studiesPartlyReal human data, but in skin and wound healing. What exists for hair is thin.PartlyOne small trial matched rosemary oil to 2% minoxidil. Caffeine has a few. That is all of it.
Available without a prescription YesOnly because there is no approved use to prescribe YesNo approved hair-loss version to prescribe. The acne cream made from the same molecule is prescription only. YesSame reason again. There is no approved version to prescribe, anywhere. YesOver the counterNoPrescription only. A doctor has to agree.Partly1% over the counter. 2% is usually a prescription. YesNo approved medicine here to prescribe YesAny shop, any time
Living with it
If you stopLoss resumesLoss resumesLoss resumesShedding within weeksLoss resumesThe flaking comes backThe scalp goes back to how it wasBack to baseline
Daily effortOnce a dayTwice a dayOnce a dayOnce or twice a dayOne tabletTwo or three times a weekOnce a dayDaily, or every washNone
Cost per month, roughly€40–50€145 at 2.5%, €230 at 5%€60–90€20–60€10–20€5–10€90€10–25€0

A comparison of mechanisms, not medical advice. Minoxidil and finasteride are approved medicines with decades of randomised trials behind them, and finasteride has the longest evidence base of anything here. RU-58841, CB-03-01 and pyrilutamide are research compounds: none of them is an approved hair-loss medicine today. The Phase 3 figures quoted for clascoterone come from the formulation another company is taking through approval, not from ours, and no cortisol data from those hair trials has been published. The pyrilutamide trial results come from the manufacturer and are not yet published. GHK-Cu is a copper peptide included here as scalp support, not as a regrowth treatment. The natural column covers topical caffeine, rosemary oil and saw palmetto, where the human data is real but thin. Prices are rough monthly estimates and vary by dose, bottle size and brand, and each assumes the routine on that product's own page. Speak to a doctor before you start or stop anything.

What else the lab makes.

BLOCK Best Seller

RU58841 Topical Solution

4.9 (88)·5/8% · 30/50/100 ml

Occupies the androgen receptor so DHT cannot deliver its signal to the follicle.

This is the cause, not the symptom. On its own it will not push a dormant follicle back into growth.

From €39,99 View
ALTERNATE Viewing

Pyrilutamide 0.5% (KX-826)

4.6 (16)·0.5% w/v · 30 mL

A newer topical androgen-receptor antagonist. Different molecule, same target as RU-58841.

For people who do not tolerate RU. Run one blocker or the other, not both.

€90,00 Waitlist
ALTERNATE COMING SOON

CB-03-01 2.5/5% (Clascoterone)

2.5/5% · 50 ml

Blocks the androgen receptor at the follicle, then breaks down in the skin into an inactive form.

The only one here that finished phase 3. Clascoterone sold much cheaper elsewhere is usually weaker than the label says.

From €89,00 Waitlist
PUSH Sold out

Minoxidil 5%

4.6 (25)·5% · 60 mL

Extends the growth phase so follicles stay active longer. It does nothing to the hormone driving the loss.

Pairs with a blocker, never replaces one. Stop it and the growth it borrowed goes back.

€60,00 Waitlist
SUPPORT COMING SOON

Ketoconazole Shampoo

An antifungal wash that handles the flaking and irritation sitting underneath a lot of shedding.

Two or three washes a week, alongside a blocker. It is not a blocker itself.

€29,99 Waitlist
SUPPORT COMING SOON

GHK-CU Copper Peptide Spray

4.5 (13)·Copper peptide · 30 mL

A copper peptide that works on the condition of the scalp itself. Not an antiandrogen; it does nothing to DHT.

For scalp quality. On its own it will not hold a receding hairline.

€50,00 Waitlist
NATURAL COMING SOON

Natural Hair Regrowth Serum

4.6 (13)·Topical · 50 mL

Caffeine, rosemary and botanical oils. Scalp support, and the mildest thing in the range.

A leg of the routine, not the whole table. It does not block DHT.

€60,00 Waitlist
FAQ

Questions, answered.

How is it different from RU-58841?

Same job, different design. Pyrilutamide is newer and built to act at the scalp then break down rather than accumulate. The usual reason to choose it is tolerance — some men find it sits better on their skin than RU. Run one blocker or the other, never both.

How do I use it?

Six to seven pumps of the spray is about 1 ml — the daily dose. Apply to a dry scalp once a day and let it dry. It is a spray pump, so you count it; there is nothing to measure.

How strong is the evidence?

Pyrilutamide has human trial data, which puts it ahead of most topicals. But that data is still limited and the picture is not fully settled. It is a research compound, not an approved medicine, and we won’t pretend the case is closed.

Are there side effects?

Being topical, it is designed to avoid the systemic effects of oral blockers, but the safety data is thinner than for approved options. Patch-test first and stop if you react.

How do I know it is genuine?

We blend it at 0.5% in the EU and an independent laboratory tests every batch before it ships. Every bottle carries its batch number, blend date and expiry.

Shipping and returns?

Shipped from the EU, usually 2–5 working days, in plain unbranded packaging. Unopened bottles can be returned within 14 days.

Science articles

Read before you start.

What the research actually says about hair loss, DHT, and the compounds people reach for.